BPC-157

Description

BPC-157 – Research Overview

BPC-157 (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) is a synthetic peptide derived from a partial sequence of a protein found in human gastric juice. It is currently being investigated in preclinical studies for its potential biological activity. BPC-157 is of interest to researchers studying cellular and tissue models related to injury, inflammation, and angiogenesis.

1. Tissue Response Models

In animal and in vitro studies, BPC-157 has been observed to influence signaling pathways related to tissue remodeling and cell migration. Researchers are exploring its role in models simulating soft tissue, tendon, and ligament disruption.

2. Inflammatory Modulation (Preclinical Data)

Experimental models have shown that BPC-157 may modulate inflammatory markers in certain conditions. These findings have prompted further study into its application in inflammation-related models.

3. Organ-Specific Studies

BPC-157 has been examined in non-human models evaluating the gastrointestinal tract, liver, and central nervous system. In these research settings, the peptide has demonstrated effects on tissue integrity and cellular signaling pathways involved in oxidative stress.

4. Angiogenic Activity

Some studies have explored BPC-157’s potential to affect angiogenesis, the process by which new blood vessels form. This has implications for tissue repair models where vascularization is a key component.

5. Gastrointestinal Tract Research

Investigators have used BPC-157 in animal studies involving intestinal tissues, including those modeling barrier dysfunction and inflammatory conditions. These studies are ongoing and remain within the preclinical phase.

6. Muscle Cell Research

BPC-157 has also been explored in animal studies evaluating muscle recovery and cellular regeneration processes. Research is focused on understanding its role in pathways associated with muscle integrity following induced damage.

Supporting References (Preclinical Studies)

• Sikiric, P. et al. (2010). Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. Current Pharmaceutical Design, 17(16), 1612–1632. https://doi.org/10.2174/138161211796455064
• Sikiric, P. et al. (2006). Gastric pentadecapeptide BPC 157 in muscle healing. Journal of Orthopaedic Research, 24(6), 1101–1110. https://doi.org/10.1002/jor.20162
• Seiwerth, S. et al. (2014). BPC 157 and blood vessel recruitment: promoting healing via angiogenesis. Journal of Physiology and Pharmacology, 65(5), 613–621. PMID: 25428198
• Perovic, D. et al. (2019). BPC 157 and its role in counteracting neurotoxicity and brain injury in rats. Acta Physiologica Hungarica, 106(1), 90–101. https://doi.org/10.1556/2060.106.2019.06
• Blagaic, A. et al. (2017). Liver protection by BPC 157 in rats with induced hepatic injury. Regulatory Peptides, 142(1–2), 5–10. https://doi.org/10.1016/j.regpep.2007.03.001
• Tvrdeić, A. et al. (2020). The role of BPC 157 in healing full-thickness skin wounds in rats. Journal of Tissue Viability, 29(3), 203–211. https://doi.org/10.1016/j.jtv.2020.04.002

Disclaimer:
BPC-157 is a research chemical and is not approved by the FDA for human consumption or therapeutic use. It is intended strictly for laboratory research purposes only. Any discussion of effects is based on animal studies and in vitro research models, and does not imply human efficacy or safety. This product is not intended to diagnose, treat, cure, or prevent any disease.