Description

What Is Ipamorelin?

Ipamorelin is a synthetic peptide—a short chain of five amino acids (called a pentapeptide)—designed to mimic the body’s natural “growth signal.” It belongs to a class of compounds known as Growth Hormone Secretagogues (GHS), which means it helps your body secrete more of its own growth hormone (GH) rather than supplying GH directly.

Ipamorelin works by binding to a specific receptor in the brain and pituitary gland called the Growth Hormone Secretagogue Receptor (GHS-R)—also known as the ghrelin receptor. Ghrelin is often called the “hunger hormone,” but it also plays a major role in growth, repair, and energy balance. When Ipamorelin activates this receptor, it triggers a natural, pulsatile (wave-like) release of growth hormone, similar to how the body releases GH during deep sleep or after exercise.

One of the main reasons Ipamorelin attracted scientific interest is its selectivity. Unlike older growth hormone–releasing peptides, Ipamorelin stimulates GH release without significantly increasing cortisol or ACTH (stress-related hormones). This makes it a clean research model for studying how GH and IGF-1 (Insulin-like Growth Factor 1) affect bone, muscle, and metabolism—without the confounding effects of stress hormone spikes.

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Introduction to GLP-2TZ

GLP-2TZ is an investigational peptide analog designed to act on glucagon-like peptide-2 (GLP-2) receptors. It incorporates sequence and structural modifications intended to enhance stability and extend plasma half-life compared with native GLP-2.

Endogenous GLP-2 is secreted by intestinal L-cells in response to nutrient ingestion and plays central roles in:

• Maintaining gut barrier integrity

• Supporting intestinal growth and mucosal repair

• Enhancing nutrient absorption

GLP-2TZ is being explored as a research-grade analog to advance understanding of GLP-2 receptor pharmacology, intracellular signaling (cAMP, PI3K), and systemic metabolic effects.

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