CJC-1295 NO DAC

Description

🧪 What is CJC-1295 (Without DAC)

CJC-1295 without DAC (Drug Affinity Complex) is a synthetic peptide analog of Growth Hormone-Releasing Hormone (GHRH). It functions as a stimulator of the body’s natural growth hormone (GH) production by acting directly on the anterior pituitary gland. Because it mimics the structure and function of natural GHRH, it promotes GH release in short bursts that align with the body’s own rhythm.

Unlike the DAC-modified version, which binds to serum albumin and remains active for several days, the non-DAC form has a much shorter half-life—measured in minutes. This makes it ideal for research focusing on pulsatile GH secretion, where brief, natural-like spikes of GH are preferred. These rhythmic pulses help maintain receptor sensitivity and support balanced GH regulation, enhancing tissue repair, metabolism, and recovery without the risk of desensitization or overstimulation.

🔬 Molecular Structure

Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Q-Glu-Gln-Gly-Ala-Ser-Ala-Arg-Leu-Gly-Glu-Gly-Gln-Ala
Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight: 3367.9 g/mol
PubChem CID: 91976842
CAS #: 863288-34-0
Other Known Titles: CJC-1295 Without DAC
Source: PubChem

⚡ Key Actions

Research on CJC-1295 (without DAC) shows a range of physiological and cellular effects related to its ability to stimulate natural GH release. Key demonstrated actions include:

• Stimulates endogenous growth hormone (GH) secretion through GHRH receptor activation.
• Enhances IGF-1 (Insulin-like Growth Factor 1) production, amplifying tissue repair and anabolic processes.
• Promotes muscle growth, protein synthesis, and recovery after physical stress or injury.
• Supports fat metabolism (lipolysis) by mobilizing fatty acids for energy use.
• Contributes to deep sleep regulation by strengthening natural GH pulse patterns during slow-wave sleep.
• Indirectly supports collagen synthesis, improving skin elasticity and wound healing.
• Helps maintain immune system function through GH/IGF-1 pathways that regulate thymic activity and immune cell turnover.
• Encourages balanced, physiological hormone rhythms without overstimulation or receptor fatigue.

These effects make CJC-1295 (without DAC) a valuable tool in research on growth hormone regulation, recovery optimization, and aging-related endocrine decline.

🔬 CJC-1295 (Without DAC): Key Research Areas and Potential Benefits

1. Growth Hormone Modulation

CJC-1295 (a GHRH analogue) has been shown in research to significantly increase circulating GH and Insulin-like Growth Factor-1 (IGF-1) levels. These hormones are critical for muscle growth, metabolism, and cellular repair. Studies have explored its use in models examining muscle hypertrophy, body composition optimization, and post-exercise recovery.

Reference:

• Vance ML, Mauras N, Thorner MO. The role of growth hormone secretagogues in the diagnosis and treatment of GH deficiency. Growth Horm IGF Res. 2003;13(4):183-198. doi:10.1016/S1096-6374(03)00047-1

2. Muscle Growth and Recovery

By triggering short GH pulses, CJC-1295 without DAC enhances protein synthesis and muscle regeneration. Preclinical studies suggest this can accelerate healing after intense training or injury by stimulating muscle cell proliferation and repair.

Reference:

• Takahashi K, Okimura Y, Shimizu S, et al. Growth hormone-releasing hormone: a potent anabolic factor in skeletal muscle. Growth Horm IGF Res. 2002;12(1):1-10. doi:10.1054/ghir.2001.0232

3. Lipolysis and Fat Metabolism

CJC-1295 has been studied for its impact on GH-mediated lipolysis, the process of converting stored fat into usable energy. GH increases circulating free fatty acids, improving fat utilization while preserving lean tissue. These effects make it a research focus for fat loss and metabolic regulation.

Reference:

• Hew FL, Kos D, Stuart MC, et al. Regulation of lipolysis in adipose tissue by growth hormone: involvement of the JAK-STAT pathway. Endocrinology. 1996;137(12):5687-5692. doi:10.1210/endo.137.12.8940364

4. Sleep Quality and Hormonal Pulsatility

Most natural GH secretion occurs during slow-wave (deep) sleep. By enhancing GH pulse amplitude, CJC-1295 may help improve sleep architecture, recovery, and circadian rhythm balance. Research suggests this pulsatile activity could restore normal sleep-related hormone cycles.

Reference:

• Van Cauter E, Leproult R, Plat L. Growth hormone secretion during sleep. J Clin Invest. 1997;100(5 Suppl):S32-S35. doi:10.1172/JCI119283

5. Skin Health and Collagen

GH and its downstream mediator IGF-1 are key regulators of collagen synthesis and dermal repair. CJC-1295’s ability to indirectly elevate GH may therefore improve skin elasticity, support wound healing, and counter age-related skin thinning.

Reference:

• Rudman D, Feller AG, Nagraj HS, et al. Effects of human growth hormone in men over 60 years old. N Engl J Med. 1990;323(1):1-6. doi:10.1056/NEJM199007053230101

6. Immune Function

Through the GH/IGF-1 axis, CJC-1295 may influence thymic regeneration—the process responsible for T-cell development—and help sustain immune function during aging. This area of research explores GH’s broader role in immune regulation and cellular defense.

Reference:

• Kelley KW, Weigent DA, Kooijman R. Growth hormone and the immune system. Crit Rev Immunol. 1990;10(1):97-127. doi:10.1615/CritRevImmunol.v10.i1.50

🚀 Mechanism of Action

CJC-1295 without DAC binds to GHRH receptors in the anterior pituitary, triggering the release of stored GH in short, physiological bursts. This pulsatile pattern mirrors natural GH secretion, promoting balanced endocrine signaling. By maintaining receptor sensitivity, it avoids the receptor “down-regulation” often associated with long-acting GH analogues or DAC-modified peptides.

💡 Future Areas of Research and Clinical Focus

• Optimized Pulsatile Dosing:
• Development of advanced dosing strategies—often paired with GH secretagogues such as Ipamorelin—to replicate the body’s natural 24-hour GH rhythm.
• Sarcopenia and Frailty:
• Clinical evaluation of its potential to reduce age-related muscle loss and improve functional strength in older adults.
• Metabolic Syndrome:
• Exploration of long-term effects on insulin sensitivity, glucose regulation, and lipid metabolism to assess therapeutic potential in metabolic disorders.