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GHK-Cu

$69.00

Research Only Purposes

Availability: 79 in stock SKU: GHK-CU+100 Category:

Description

Introduction to GHK-Cu (Research Use Only)

GHK-Cu, also known as Copper Tripeptide-1, is a naturally occurring peptide composed of three amino acids: glycine, histidine, and lysine. Its sequence—Gly-His-Lys—binds copper ions to form a biologically active complex. Discovered by Dr. Loren Pickart in the 1970s, GHK-Cu has been extensively studied for its role in cellular signaling, tissue remodeling, and regeneration in laboratory settings.

Due to its unique biochemical profile, GHK-Cu is of ongoing interest in research across dermatology, regenerative biology, and aging-related models.

Key Research Areas

1. Wound Healing and Tissue Regeneration

In preclinical models, GHK-Cu has been shown to support the remodeling of extracellular matrix components, including upregulation of collagen and glycosaminoglycans. Studies have explored its potential in wound closure, skin integrity, and tissue repair dynamics.

2. Skin Biology and Aging Models

GHK-Cu has been investigated for its effects on fibroblast activity, skin elasticity, and hydration. Research indicates increased gene expression linked to hyaluronic acid and elastin synthesis, which are relevant in skin regeneration and age-related degradation.

3. Inflammatory Modulation

Laboratory studies have examined GHK-Cu’s role in cytokine regulation and anti-inflammatory activity. These models assess its ability to reduce pro-inflammatory signals, particularly in chronic inflammation scenarios.

4. Hair Follicle Research

Research indicates that GHK-Cu may influence dermal papilla cells and improve scalp microcirculation. These effects are being studied in models focusing on follicular health and hair density.

5. Cellular Protection from UV Radiation

Studies suggest GHK-Cu may help mitigate oxidative stress and DNA damage following ultraviolet exposure. It has been included in experimental models focused on photoprotection and UV-induced skin aging.

6. Antioxidant Activity

GHK-Cu has been associated with antioxidant pathways and copper-dependent enzymes like superoxide dismutase (SOD). Research explores its impact on free radical reduction and oxidative balance.

7. Oncological Research

In vitro studies have explored GHK-Cu’s possible role in influencing apoptosis and regulating cancer cell proliferation. These findings remain preliminary and are part of broader cancer biology models.

8. Cognitive Function and Neurobiology

GHK-Cu has been evaluated in neuroregeneration models, particularly in relation to brain-derived neurotrophic factor (BDNF), synaptic repair, and age-related cognitive resilience.

9. Joint Research and Inflammatory Models

Studies in joint tissue and arthritis models have examined GHK-Cu’s regenerative effects, particularly its role in cartilage signaling, synovial recovery, and joint tissue structure.

10. Muscle and Connective Tissue Recovery

GHK-Cu has also been used in animal models exploring muscular regeneration, fibrosis modulation, and post-exertion recovery, especially in relation to inflammation and oxidative damage.


Supporting References (Preclinical Studies)

  • Pickart, L., & Margolina, A. (2018). Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. International Journal of Molecular Sciences, 19(7), 1987. https://doi.org/10.3390/ijms19071987
  • Kennedy, B. G. et al. (1992). Copper peptide GHK-Cu stimulates collagen and glycosaminoglycan synthesis by fibroblasts. Connective Tissue Research, 28(1–2), 123–134. https://doi.org/10.3109/03008209209014245
  • Maquart, F. X. et al. (1993). Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex GHK-Cu. FEBS Letters, 238(2), 343–346. https://doi.org/10.1016/0014-5793(88)80509-4
  • Fischer, M. et al. (1997). GHK-Cu modulates inflammatory gene expression in human skin fibroblasts. Inflammation Research, 46(2), 51–57. https://doi.org/10.1007/s000110050266
  • Babygirija, R. et al. (2011). Copper peptide improves recovery of inflamed colon via angiogenesis and epithelial cell regeneration. American Journal of Physiology – Gastrointestinal and Liver Physiology, 301(2), G199–G207. https://doi.org/10.1152/ajpgi.00408.2010

Disclaimer:
GHK-Cu is a research chemical and is not approved by the FDA for human consumption or therapeutic use. It is intended strictly for laboratory research purposes only. Any discussion of effects is based on animal studies and in vitro research models, and does not imply human efficacy or safety. This product is not intended to diagnose, treat, cure, or prevent any disease.

Additional information

CAS

89030-95-5

MG

100

Brand

Sovereign Health and Performance

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