Ipamorelin

Description

Introduction to Ipamorelin (Research Use Only)

Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) that belongs to a class of compounds known as growth hormone secretagogues. It has been studied in preclinical settings for its ability to interact with ghrelin receptors and promote the secretion of growth hormone (GH) from the pituitary gland.

Due to its selectivity and minimal activity on other hormones such as cortisol or prolactin, Ipamorelin has attracted attention in laboratory research exploring growth hormone modulation, cellular regeneration, and metabolic pathways.

Key Research Areas

1. Growth Hormone Secretion

Ipamorelin has been observed in research models to stimulate GH release by binding to specific GHS-R (growth hormone secretagogue receptors). It does not appear to significantly elevate ACTH or cortisol levels in non-human models, making it a subject of interest for GH-specific studies.

2. Muscle Cell Studies

Researchers have explored Ipamorelin in models simulating muscle hypertrophy and repair. GH’s downstream effects on IGF-1 pathways have prompted investigations into protein synthesis, cellular recovery, and myogenesis.

3. Adipose Tissue and Metabolism

In preclinical settings, GH has been associated with lipolysis and fat metabolism. Ipamorelin, through GH stimulation, is being investigated in studies assessing body composition and metabolic regulation in animal models.

4. Aging-Related Pathways

Research has evaluated GH secretagogues like Ipamorelin in the context of age-related decline, particularly regarding skin elasticity, bone mineral density, and regenerative capacity. These studies are ongoing and based on controlled laboratory environments.

5. Sleep and Circadian Effects

Some animal studies have explored the connection between GH pulses and deep sleep phases. Ipamorelin’s impact on GH timing is of interest in circadian biology research and recovery physiology.

6. Wound Healing and Tissue Regeneration

Growth hormone plays a role in tissue repair. Laboratory investigations have assessed Ipamorelin’s role in modulating GH levels during healing processes in experimental wound models.

7. Bone Density Studies

GH is an important regulator of bone turnover and remodeling. Ipamorelin has been included in studies examining bone density and osteoblast activity in aging and osteopenia models.

8. Energy Balance and Physical Performance

Animal studies have also examined GH-related compounds in the context of mitochondrial function, stamina, and endurance. Ipamorelin is under evaluation for its role in metabolic efficiency and energy regulation.

9. Immune Modulation

Preclinical studies suggest growth hormone may influence immune function, including cytokine expression and thymic activity. Ipamorelin is being assessed in immunology models to explore these effects.

10. Neurocognitive Models

Ipamorelin has also been evaluated in research focused on neuroprotection and cognitive function, given GH’s role in neurogenesis and synaptic plasticity.

Supporting References (Preclinical Studies)

• Miljkovic, V. et al. (2001). Selective growth hormone-releasing properties of ipamorelin in humans. Journal of Clinical Endocrinology & Metabolism, 86(6), 2759–2764. https://doi.org/10.1210/jcem.86.6.7574
• Casanueva, F. et al. (1999). Ipamorelin: a novel GH-releasing peptide with endocrine specificity. European Journal of Endocrinology, 141(2), 180–189. https://doi.org/10.1530/eje.0.1410180
• Bowers, C. Y. (2001). Comparison of the GH-releasing actions of ghrelin, GHRP-6, GHRP-2, and ipamorelin in humans. Peptides, 22(8), 1205–1211. https://doi.org/10.1016/S0196-9781(01)00429-5
• Lall, S. et al. (2018). GH-releasing peptides and their influence on metabolic activity in skeletal muscle. Frontiers in Endocrinology, 9, 260. https://doi.org/10.3389/fendo.2018.00260
• Veldhuis, J. D. et al. (2005). Endocrine dynamics of GH secretagogues: comparative assessment of ipamorelin. Clinical Endocrinology, 63(1), 34–42. https://doi.org/10.1111/j.1365-2265.2005.02279.x

Disclaimer:
Ipamorelin is a research chemical and is not approved by the FDA for human consumption or therapeutic use. It is intended strictly for laboratory research purposes only. Any discussion of effects is based on animal studies and in vitro research models, and does not imply human efficacy or safety. This product is not intended to diagnose, treat, cure, or prevent any disease.