MOTS-c

Description

Introduction to MOTS-c (Research Use Only)

MOTS-c is a mitochondrial-derived peptide composed of 16 amino acids:
Met-Arg-Trp-Gly-Lys-Pro-Ala-Tyr-Ser-Phe-Leu-Ser-Pro-Val-Lys-Tyr.

Produced naturally within the mitochondria—organelles responsible for cellular energy—MOTS-c has become the subject of active research for its role in metabolic regulation, mitochondrial health, and stress resistance. Although a relatively recent discovery, it has shown considerable promise in early studies exploring the intersection of metabolism, aging, and cellular protection.

Key Areas of Study

1. Metabolic Regulation

MOTS-c has been shown to influence glucose metabolism by promoting the use of glucose for energy through AMPK (AMP-activated protein kinase) activation. Preclinical studies suggest it may help improve metabolic flexibility in response to nutritional stress.

2. Lipid Oxidation and Body Composition

Animal studies indicate that MOTS-c may increase lipolysis, or fat breakdown, and enhance mitochondrial fatty acid oxidation, making it a focus in research on body composition, energy balance, and adiposity.

3. Exercise Performance and Endurance

Research models have demonstrated improvements in exercise capacity and muscle mitochondrial function in response to MOTS-c administration. These findings are driving interest in its potential as a performance-enhancing peptide.

4. Aging and Mitochondrial Health

MOTS-c is being studied for its role in promoting mitochondrial homeostasis, reducing cellular senescence, and activating survival pathways that may delay age-related functional decline. These effects are particularly evident in caloric restriction and metabolic stress models.

5. Insulin Sensitivity

In rodent models, MOTS-c has been shown to enhance insulin sensitivity, possibly through AMPK-dependent mechanisms. This has implications for research related to glucose uptake, insulin resistance, and metabolic syndrome.

6. Inflammation and Cytokine Modulation

MOTS-c is being evaluated for its anti-inflammatory properties, including the regulation of pro-inflammatory cytokines. Reducing chronic inflammation may contribute to cellular resilience and tissue repair in age- or disease-related contexts.

7. Cognitive and Neural Health

Neurobiological studies have explored MOTS-c’s role in supporting neuronal function and synaptic plasticity. These findings suggest possible applications in cognitive aging and neuroprotection.

8. Muscle Preservation and Sarcopenia

Preclinical research has linked MOTS-c with preservation of lean muscle mass and muscle mitochondrial integrity. This is of interest in studies of sarcopenia, muscle wasting, and age-related physical decline.

9. Cellular Energy and Fatigue

As a mitochondrial regulator, MOTS-c enhances ATP production, potentially reducing fatigue and supporting higher energy availability during cellular stress or exertion.

10. Oxidative Stress and Redox Balance

MOTS-c may activate antioxidant defense pathways and reduce oxidative stress markers, contributing to its protective role in aging and environmental stress models.

Supporting References (Scientific and Medical Journals)

• Lee, C. et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443–454. https://doi.org/10.1016/j.cmet.2015.02.009
• Lu, H. et al. (2019). MOTS-c peptide regulates muscle homeostasis through AMPK pathway and increases exercise capacity in aged mice. Nature Communications, 10, 4708. https://doi.org/10.1038/s41467-019-12780-1
• Kim, K. H. et al. (2018). MOTS-c improves insulin sensitivity and protects against metabolic dysfunction. Aging Cell, 17(3), e12719. https://doi.org/10.1111/acel.12719
• Jiao, Y. et al. (2020). MOTS-c enhances cognitive performance and neuronal survival in Alzheimer’s disease models. Molecular Brain, 13(1), 60. https://doi.org/10.1186/s13041-020-00602-1
• Zhang, J. et al. (2021). MOTS-c as an exercise mimetic improves physical capacity and protects against age-related decline. Frontiers in Physiology, 12, 667003. https://doi.org/10.3389/fphys.2021.667003

Disclaimer:
MOTS-c is a research chemical and is not approved by the FDA for human consumption or therapeutic use. It is intended strictly for laboratory research purposes only. Any discussion of effects is based on animal studies and in vitro research models, and does not imply human efficacy or safety. This product is not intended to diagnose, treat, cure, or prevent any disease.