NAD+

Description

Description

Notice: This item is provided strictly for laboratory research and analytical purposes. It is not intended for human or animal use of any kind. Experimental application must remain within controlled, in vitro environments. All content is for scientific education and reference only. This material is not a food, drug, or cosmetic and must not be misrepresented or misused as such. Handling is restricted to trained and properly licensed professionals.

Detailed Overview

Introduction to Nicotinamide Adenine Dinucleotide (NAD⁺) – Research Use Only

NAD⁺ is a pivotal coenzyme found in all living cells, playing a vital role in redox reactions, energy metabolism, and cell signaling. In the lab, researchers harness NAD⁺ to explore fundamental processes in metabolism, aging, mitochondrial function, and DNA repair.

Key Research Focus Areas

1. Energy & Redox Biology
NAD⁺ functions as a hydrogen- and electron-carrier essential for glycolysis, the citric acid cycle, and oxidative phosphorylation, enabling cells to convert nutrients into usable energy.

2. Aging & Sirtuin Activity
As an essential cofactor for sirtuin enzymes, NAD⁺ is central to research investigating lifespan extension, cellular stress resistance, and age-associated decline.

3. DNA Repair & Genomic Stability
NAD⁺ is required by PARP enzymes involved in DNA damage response. Studies often use NAD⁺ supplementation or depletion to probe DNA integrity and repair mechanisms.

4. Mitochondrial Health & Function
Research indicates that NAD⁺ levels influence mitochondrial biogenesis, mitophagy, and oxidative capacity—making it crucial for studies on metabolic resilience.

5. Cellular Signaling: Inflammation & Circadian Rhythm
NAD⁺ is involved in modulating inflammatory responses and circadian regulation via enzymatic pathways like CD38 and SIRT1.

6. Potential Sexual Health Benefits
Although NAD⁺ is not intended for human use, researchers have noted that its roles in mitochondrial energy output, vascular function, and nitric oxide signaling suggest potential links to sexual health. Preclinical investigations highlight improved endothelial function and enhanced circulation, mechanisms that could theoretically support libido, erectile function, and overall sexual vitality. These findings remain strictly experimental and are the subject of ongoing laboratory research.

Supporting References (Scientific Journals)

• Imai S-I, Guarente L. NAD⁺ and sirtuins in aging and longevity control. Trends Cell Biol. 2014;24(8):464-471.
• Yoshino J, Baur JA, Imai S-I. NAD⁺ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018;27(3):513-528.
• Zhou C, Sinclair DA. Mitochondrial fitness, NAD⁺ and longevity. Trends Endocrinol Metab. 2019;30(3):493-506.
• Bai P, et al. PARP-1-paraBAD NAD⁺ regulate DNA repair. Trends Biochem Sci. 2011;36(6):324-335.
• Stanhewicz AE, Kenney WL. Role of nitric oxide in human cutaneous microvascular function: new insights into vascular regulation and sexual health. Am J Physiol Heart Circ Physiol. 2017;312(2):H287-H295.
• Burnett AL, Musicki B. The nitric oxide signaling pathway in the penis. Int J Impot Res. 2005;17(S1):S99-S107.